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KMID : 0357919850190010051
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Korean Journal of Pathology
1985 Volume.19 No. 1 p.51 ~ p.57
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Study on the Natural History of Hepatitis B Virus-infected Rats, and its Relationship with Chemical and Physical Injury of the Liver
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석동수(石東壽)/Dong Soo Suk
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Abstract
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Normal, hepatectomied (partial) or CCI, injected rats are infected intraperitoneally with
human HBV, infected serum, and histopathological examination of major organs, and
serologically HBV markers are checked. In the latter groups, the relationship between
the regenerating hepatocytes and their infectivity toward HBV are investigated.
1) There are no specific histological changes in the liver which might suggest HBV
infection of hepatocytes.
2) There is a tendency to increase basophilic mononuclear cells in the lymphoid
organs. At the same time, HBcAb are positive in the rats' serum suggesting that these
cells are immunologically oriented effector cells in the defense system. In the groups
which received hepatic injury, the number of these cells are decreased.
3) HBcAb are positive in the groups of 5 th day, 1 week, and 2 weeks post-HBV
injection. All groups with hepatic injury show trace in the 2 weeks post-HBV injection
which corresponds to the concomitant decreased number of basophilic mononuclear cells
in the lymphoid organs.
4) Above findings suggest that HBV will promote a proliferative reaction of the
mononuclear cells in the lymphoid organs in the early stage of HBV infection. It appears
that the infection stops there, and there would be no activation of the mechanism of
antibody-dependent cellular cytotoxicity followed by injury of hepatocytes due to the
attack of T-lymphocytes manifesting the clinical hepatitis.
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